OBJECTIVES:  To explore Drug Information Centers practice in Saudi Arabia: with emphasis on Medication-Use Evaluation services at MOH METHODS:  It is a national survey of Drug Information Services at MOH. It consisted of a demographic section and ten domains with 181 questions. The ten areas included; Leadership and Practice Management, Medication Addition and Deletion System, Hospital Formulary System, Medication Safety System, Professional, and Public Education. The Evidence Based Medicine-Therapeutics Guidelines, Medication-Use Evaluation (MUE), Pharmacoeconomics System, Investigational Drug Services (IDS) and Professional Publications Services (PPPS), and Ethical and Legal Issue. It drove from International pharmacy standard and best practice guidelines. The domain of Medication-Use Evaluation explored and analyzed. RESULTS:  The survey distributed to forty-five of hospitals, the response rate, was 40 (88.88%) hospitals. Of that, 35 % were large hospitals and 37.5 % were medium-sized hospitals. The organizational authority for the MUE process found at 26 (65%) of hospitals and the indicators for comprehensive surveillance of the medications use system existed in 24 (60%) hospitals. The priorities aspects of MUE existed in 24 (60%) hospitals. The informality of health-care professionals objectives and expected benefits of the MUE process exist in 25(62.5%). The Criteria, guidelines, treatments protocols and standards of care for specific medications existed in 26 (65%) hospitals applied 25-100% the elements. Educate health-care professionals to promote the use of criteria, guidelines, treatment protocols, and standards of care existed in 27 (67.5%) hospitals. The implementation plan for improvement of the medications uses exist in 25 (62.5%) hospitals. CONCLUSIONS:  There was an incomplete implementation of Medication-Use Evaluation in drug information centers practice. Establishing strategic planning of Medication-Use Evaluation system and set up an educational program for drug information pharmacist, will improve Medication-Use Evaluation practice.