OBJECTIVES: Chile has recently included a multidimensional poverty (MDP) index in population surveys. It considers 12 indicators gathered into 4 dimensions for household level MDP. About 20% of the population has multidimensional poverty. We explored the relationship between Self-Rated Health (SRH), MDP and barriers of healthcare access in Chilean adults during 2013. METHODS: Using data of >15 years old from the 2013 CASEN survey (n=85139, equivalent to N=6.718.477), we estimated multiple ordinal regression models with partial proportional odds and log complementary link, where SRH (3 categories: good/regular/bad) was the dependent variable; MDP (poor/non-poor) and barriers to access to healthcare (yes/no) were the independent variables. We then adjusted for covariates (sex / age / educational level / immigrant status / ethnicity / occupation / marital status / household income). RESULTS: SRH was associated with MDP ([OR=0.86, 95%CI [0.88-0.91]) and with barriers to access to health. Individuals with barriers to access to healthcare were less likely to move from a "poor health" to a "moderate to good health" (OR=0.68, 95%CI [0.66-0.69]). This was even more accentuated when moving from "bad or moderate" to "good health" (OR=0.54, 96%CI [0.52-0.55)]. The association between SRH, MDP and barriers of access was maintained after multivariate adjustment for socio-demographic covariates. CONCLUSIONS: Barriers to healthcare showed a strong association with SRH in Chilean adults, even after adjusting for MDP and other socio-demographic covariates. Both MDP and barriers to access are potentially modifiable determinants of SRH that need urgent attention at health policy level in this country.