OBJECTIVES:  The main objective of our study was to assess the knowledge of women in Siklós and its region about the human papillomavirus and also learn their attitudes about the vaccine. METHODS:  A quantitative, cross-sectional survey was carried out in 2016 by using non-random sample selection method in Siklós and its region. 180 questionnaires were distributed, of which 166 proved to be evaluable. The questionnaire included the following groups of questions: socio-demographic profile, knowledge on human papilloma virus and willingness to vaccination. Data were processed by SPSS 22.0 program, using descriptive statistical analysis, χ-test, Mann-Whintey-test and Logistic regression (p<0.05). RESULTS: =24.960; p<0.001), with health education (χ=16.738; p<0.001), and with knowledge of the acronym, HPV (χ=16.427; p=0.001) knew the promoting factors of the infection. Women giving birth later in life were likely to give a wrong answer on diseases caused by HPV (ß=0.167; OR= 1.182; 95% CI[1.032;1.353]). Women with health education (Mann-Whitney U=1005.500; p<0.001) had a significantly higher level of knowledge than those without it. In total, 33.7% of the women could be considered as persons with high level of knowledge on HPV. Women with higher education significantly knew more on HPV (χ=35.111; p<0.001). 81.9% of the respondents had some knowledge on HPV vaccination and 4.2% of them received vaccination.30.7% of them may have vaccination later, especially those who consider their states of health good (χ=20.120; p<0.001) or those who attend cervical screening regularly (χ=15.147; p=0.019) in a higher rate. CONCLUSIONS:  To enhance knowledge is the best way to express the importance of infection. Acquired knowledge may determine the participation in screening and willingness to vaccination.