OBJECTIVES:  Beginning on October 1, 2015, International Statistical Classification of Diseases, or ICD-10 coding was implemented in the US healthcare system. Number of procedure codes increased from 3,882 to 71,974 in ICD-10. The change has implications of coding infrastructure and potentially reimbursement. Goal of the study was to describe how commonly performed surgeries are coded using ICD-10. METHODS:  We used Premier hospital inpatient database for Q4,2015 (first full quarter with ICD-10 data). We identified discharges with a primary diagnosis and relevant Medicare Severity-Diagnosis Related Group (MS-DRGs) for hysterectomy (734-743). Descriptive analysis was conducted to report the top ICD-10 procedure codes. RESULTS:  8,975 discharges were identified for hysterectomy, with MS DRGs 734-743 and relevant primary diagnoses codes, the top three including: 1) D259: Leiomyoma of Uterus, Unspecified, with 2,201 discharges; 2) D251: Intramural Leiomyoma of Uterus, with 760 discharges and; 3) C541: Malignant Neoplasm of Endometrium with 625 discharges. Top primary procedures included: 1) OUT90ZZ: Resection of Uterus, Open Approach, with 4,211 or 46.92% of discharges; 2) OUT94ZZ: Resection of Uterus, Percutaneous Endoscopic Approach (PEA), with 872 (9.72%); 3) OUT9FZZ: Resection of Uterus, Via Natural or Artificial Opening, with PEA, with 646 (7.2%); 4) OUB90ZZ: Excision of Uterus, Open Approach, with 561 (6.25%) and; 5) OUT97ZZ: Resection of Uterus, Via Natural or Artificial Opening, with 547 (6.1%). CONCLUSIONS:  We report the first, real-world experience of ICD-10 coding. Code for open abdominal hysterectomy was reported in nearly half of hysterectomy procedures and was the single most commonly used procedure code.