OBJECTIVES:  Health related quality of life (HRQoL) for Chinese general population is important to decision-maker. The aim of this study was to conduct a systematic review which is based on an EQ-5D-3L questionnaire in China to evaluate HRQoL for general population. METHODS: To identify studies related to HRQoL for general population in China, both English and Chinese literatures published from January 1990 to August 2015 were systematically searched by using PubMed, EMbase, the Cochrane Library, VIP WanFang Data and CNKI databases. A descriptive analysis was performed to study health utility, VAS scores, and proportion of people who have problems in five dimensions of EQ-5D-3L. RESULTS: In total, 17 studies were identified in this research, all age population and elderly population were included. As for all age population, the health utility ranged from 0.80 to 0.96 while VAS scores ranged from 77 to 86. In the majority studies, the dimension with highest proportion of people having problems was “Pain/discomfort”, followed by “Anxiety/Depression”, while “Self-Care” dimension was the lowest one. For male, the utility values and VAS scores were higher than female, suggesting a better HRQoL of men. People living in rural areas were with lower health utility than urban residents, but VAS score was on the contrary. As for aged population, the utility values ranged from 0.79 to 0.89. The findings of that dimensions with highest and lowest proportion of people having problems for aged population were the same in all age population. CONCLUSIONS:  EQ-5D-3L is wildly used in HRQoL studies for Chinese general population. The sample source and the usage of different utility value set might have influence on measurement results.