OBJECTIVES: To assess the health-related QoL of hypertensive patients in southwest China and compare it with other area in China, and identify the factors that influence the QoL of hypertensive patients. METHODS: Face to face survey was conducted to 600 samples of hypertensive patients who were recruited from tertiary hospitals in Chengdu, the biggest southwest city in China. Sociodemographic of patients were collected through questionnaires, and health-related quality of life were measured using the EQ-5D-5L scale. Chi-square test, one-way analysis of variance (ANOVA) and student's t test were employed to estimate the differences between various sociodemographic conditions. RESULTS: