OBJECTIVES: To perform an economic evaluation study of the endoscopic system (Da Vinci®) as treatment for patients with lung cancer in Mexico. METHODS:  Justified by the results from a systematic review of the clinical literature previously developed, that conclude that the health benefits in terms of decrease in mortality and surgical complications were similar, a cost minimization analysis was developed in comparison with Video-assisted thoracoscopic lobectomy (VATL). The analysis was performed from the National Health System perspective. This evaluation also considered only direct medical costs took from institutional sources. The temporal horizon was determined immediate, i.e., the duration of time of the surgical interventions in comparison, it was not included a social discount rate. The analysis also included the equivalent annual cost through the calculation of the annuity factor. With the purpose of analyze uncertainty, a univariate deterministic sensitivity analysis was done, it contemplated variation in the cost of the surgical system Da Vinci, cost of consumables used and the number of annual surgeries done by the public health services from Mexico. RESULTS:  The use of Da Vinci surgical system in the treatment of lung cancer generates a cost per surgical intervention of $4,367.6642 USD, and $6,041.9646 USD in the case of VALT, the use of Da Vinci surgical system generates a save per intervention of $1,674.3004 USD. CONCLUSIONS:  The use of Da Vinci surgical system in the treatment of lung cancer is an equally safe and efficacious strategy than the one available nowadays in the National Health System, but with less cost per surgical intervention. From an institutional perspective, the use of Da Vinci surgical system is a cost saving strategy.