OBJECTIVES: To compare and analyze the differences of EQ-5D-5L values derived from UK, Japan and China preference weights using a sample of patients with psoriasis vulgaris in Mainland China. METHODS:  A convenience sampling framework was adopted and a face-to-face interview approach was used for data collection. The Friedman Test and The Wilcoxon signed-rank tests were used to examine the differences of EQ-5D-5L utility scores derived from three tariffs. The ICCs and Bland-Altman plots were used to study the agreement among the three EQ-5D-5L scores. The Spearman's rho correlation coefficients was adopted to examine the correlation between EQ-5D-5L utility scores and a series of quality of life scores measured based on Visual Analogue Scale (VAS) scores, Psoriasis Area Severity Index (PASI) scores, and Psoriasis Disability Index (PDI) scores. The differences on quality of life scores between different severities of psoriasis vulgaris were tested by using the Mann-Whitney U test. RESULTS:  A total of 350 patients (aged 16 years or older) were recruited. There were significant differences among the three national tariff sets. The EQ-5D-5L scores using the China weights yielded the largest range (0.30–1.00), whereas those scores derived from Japan and UK preference weights had smaller range (0.45-1.00 and 0.34–1.00, respectively). Overall, three tariffs showed excellent agreement (ICC>0.90). The EQ-5D-5L scored using the China tariff had better discriminated validity than the other two tariffs. CONCLUSIONS:  Three country-specific EQ-5D-5L tariffs have shown a high level of agreement based on psoriasis vulgaris patients in Mainland China. Having said that the Chinese-specific tariff had the best the best discriminated validity. It is recommended that the country-specific tariff is preferred for use in Mainland China. if not available, the value sets should be developed, or we also can use UK or other country tariffs with same cultural background. However, more research needs to be done.