OBJECTIVES:  Cystic fibrosis-related diabetes (CFRD) is a distinct form of diabetes mellitus that is an important complication of cystic fibrosis (CF). The principal cause is a relative insulin deficiency related to destruction of pancreatic islets. Insulin resistance also may play a role, especially in association with acute exacerbations or chronic progression of pulmonary disease. Our objective is to characterize CFRD patients, their healthcare utilization, as well as associated hospitalization costs. METHODS:  We conducted a cross-sectional study of CFRD patients (ICD-9 277.09) from the 2012 Nationwide Inpatient Sample (NIS). A prevalence estimate for CFRD was established using the discharge weight that was included in the NIS for each observation; however all other analysis did not include the discharge weight. We compared patients with CF (ICD-9 277.00, 277.01, 277.02, 277.03) to those with CFRD on length of stay (LOS) and total cost using chi-square test of association. RESULTS:  We estimated US prevalence of inpatients with a diagnosis of CFRD at 4,060 cases. CFRD patients were similar in age, with an average age of 23.26 versus 23.08 years (p<0.0231) in their non-diabetic CF peers. Hospitalizations associated with CFRD patients had significantly greater LOS, 10.59 days compared to non-diabetic patients 8.86 (p<0.001) and number of comorbidities 5.21 versus 4.29 (p<0.001). As well, CFRD patients had greater mean cost of hospitalizations, $99,772.82 versus $76,607.43 (p=0.4719). CONCLUSIONS:  CFRD patients have increased medical cost, increased length of stay, and increased disease severity compared to those without diabetes.