OBJECTIVES: To evaluate the prevalence and patterns, and covariates of concomitant use of complementary and alternative medicine (CAM) and Antiretroviral Therapy (ART) and the impact on ART adherence and viral load suppression among HIV-infected patients engaged in care in Houston/Harris County, Texas. METHODS: Data used for this study were obtained from the Medical Monitoring Project (MMP) survey conducted in Houston/Harris County, Texas between 2009 and 2013. We estimated the prevalence and patterns of concurrent use of CAM and ART among persons receiving HIV medical care in the past 12 months, and determined the relationship with ART adherence and viral load suppression. The data obtained were subjected to descriptive and inferential statistics using the SAS software version 9.4. RESULTS:  Concomitant use of CAM and ART (CAM-ART) was significantly (p<0.0001) more prevalent among Whites (44.9%, 95% CI: 33.4-56.4) than blacks (34.0%, 95%CI: 24.6-43.4) and Hispanics (17.1%, 95%CI: 9.3-24.9). CAM-ART use increased significantly (p<0.0001) with age and education, peaking at age 45-54 years (42.1%, 95% CI: 32.7-51.6) and among those educated beyond high school (62.0%, 95%CI: 49.9-74.1). More males than females used this self-management approach (79.3% vs. 18.7%, p<0.0001). Common CAM modalities used include biologically based therapies (84.5%), mind–body medicine/manipulative body-based therapies (25.4%), spiritual healing (14.2%), and energy therapies (2.4%). Among CAM-ART users, 83.5% (p<0.0001) were adherent to ART. We noted no significant variations in viral load suppression among CAM-ART users and non-users. CONCLUSIONS:  The use of these therapies is suggestive of complementary roles rather than as substitutes for ART. However, it is very important that CAM-ART users consult with their clinicians to avoid any potential side effects or interactions with ART, and to ensure patient safety. Further research is needed to explore reasons for use and the possible health benefits or risks associated with long term use of CAM.