OBJECTIVES: Calcium channel blockers (CCBs) was associated with lower blood pressure variability (BPV) than other classes of antihypertensive drugs. Nonetheless, the correlation within CCBs group is unclear. This study aimed to assess the effect of Amlodipine versus other CCBs on BPV. METHODS:  A retrospective propensity score-matched analysis was conducted, which retrieved 6,995 hypertensive inpatients encounter data (with median age at 69 years old, 52% was female, diastolic blood pressure (DBP) ≥40 mmHg and <150 mmHg; systolic blood pressure (SBP) ≥70 mmHg and <260 mmHg), who took at least one antihypertensive agent and completed at least three SBP measurements during the visit. International Classification of Diseases (ICD-10) was used to identify the hypertensive patients. BPV was calculated with standard deviation of SBP during a single inpatient visit. The Propensity Score Matching (PSM) was used to balance the cohort of patients prescribed Amlodipine or other CCBs. Series of appropriate statistical tests were applied to the propensity score-matched sample to examine the different effects on BPV. Additionally, the hypertensive patients with comorbidity i.e. Coronary Artery Disease (CAD), Diabetes Mellitus (DM), Myocardial Infarction (MI), Heart Failure (HF) and Chronic Kidney Disease (CKD) were analysed. RESULTS: For the hypertensive patients (n=2004, for each cohort), patients prescribed Amlodipine had lower BPV than patients prescribed other CCBs (12.7 mm Hg vs. 13.6 mm Hg, p<0.05). For the hypertensive patients with comorbidity (n=1242, for each cohort), patients prescribed Amlodipine had lower BPV than patients prescribed other CCBs as well (13 mm Hg vs. 13.7 mmHg, p<0.05). CONCLUSIONS:  Amlodipine was associated with lower BPV than other CCBs for both hypertensive patients and hypertensive patients with comorbidity.