OBJECTIVES:  To explore the communications and relationships factors of Pharmacist Job satisfaction in Saudi Arabia METHODS:  It is a 4-months cross section survey of communication and relationships factors on Pharmacist Job satisfaction in Saudi Arabia. The study consisted of forty-three questions divided into two-part demographic information and the second part was the questions about communication and relationships factors of pharmacy job. It included pharmacy supervisors, relationship with coworkers, and pharmacist interaction with other healthcare providers, the customer interaction, and overall job satisfaction. The 5-points Likert response scale system closed and ended questions used. The survey made as an electronic format, and it analyzed through survey monkey system RESULTS: The total responders were two hundred and forty-two. Of those 214 (91.8 %) was Saudi and 33 (8.2%) was non-Saudi. The gender distribution 169 (70.7%) 55.8%) was male, and 70 (29.3%) was female. The majority of them 202 (84.2%) were in age (20-39). The most educational level of the responders was pharmacy diploma level was 97 (40.6%) and pharmacy bachelor degree 98 (41%). Most of the current position was pharmacy technician 78 (34.1%) and staff pharmacist 78 (34.1%) and worked at inpatient pharmacy 73 (34.9%), and outpatient pharmacy 83 (39.7%). The average satisfaction score of pharmacy supervisors' factors was (2.99) the pharmacist relationship with coworkers was (3.68), pharmacist interaction with other healthcare providers' factors was (3.34), and the customer interaction factors were (3.29). Most of the pharmacist found the challenges at their job were (78%). Some responders wished to change their pharmacy career (43.4%) while (63.4%) liked to stay in the pharmacy field. CONCLUSIONS:  Most of the pharmacists not satisfied with their job because of the supervisor relationship. The pharmacy supervisors of hospital pharmacies demanded of management tools and communication skills with their colleagues