OBJECTIVES: The problem of treatment of extensive burns remains one of acute problem of medicine. In the Republic of Kazakhstan burns are between 3.5% and 5% of all injuries. When wound is too deep the extensive wound surface becomes a cause of metabolic imbalance and homeostasis. Because of short of donor resources long-term existance of burn surface leads to consumption, multiple organ dysfunction syndrome and to fatality that brings significant economic losses to society. Despite existing of various types of synthetic and biological coatings the allogeneic skin up to date is "gold standard" in management of extensive burn wounds. The best way to solve problem of shortage of allogeneic skin is development of cadaveric donation. Objective: authors evaluated clinical efficacy and cost efficiency of cadaveric allograft skin grafting in management of extensive burns according to data of researches available in database of evidence-based medicine. METHODS: Review of literature was conducted on safety and efficacy of cadaveric allograft skin grafting in databases PubMED, Cochrane Library, NICE, Clinical Trials, TripDatabase etc. according to research issues (PICOs) and key words. RESULTS: After literature review of 17928 sources, relevant for criteria PICOS reports were selected for study, 19 of which were taken for final analysis. The remaining publications were excluded due to noncompliance with criteria of research questions. CONCLUSIONS: Results of 19 studies demonstrate clinical efficacy and cost efficiency of technology. Main way of cadaveric allograft skin application is temporary wounds closure after necrectomy when own donor resources is not available. According to foreign burn centers data cadaver skin application after escharotomy in management of extensive burns can reduce mortality rate and hospital stay duration. Compared with currently available synthetically temporary provisional bandages cadaveric allograft skin is more cost-effective. Recommendations based on this study to establish skin bank for cadaveric donation development were given to health policy makers.