OBJECTIVES: "De Todo Corazón" (DTC) is a risk management program with the aim of reducing complications and improving the quality of life of patients with cardiovascular risks. The aim of this study was to estimate the disease burden of cardiovascular disease and chronic kidney disease and describe its impact on the health of the population under program care. METHODS: Disability adjusted life years (DALYs) for cardiovascular disease and chronic kidney disease, resulting from the sum of loss of health due to premature death and disability was calculated. For the calculation of life years lost the death registration on the Program DTC for the period between January and December 2015, as well as the abridged life tables for the years lived with disability, the individual records of outpatient and inpatient service June 2014 and December 2015, bibliography and a map of weighted disability in the global study of the burden of disease were consulted. For data processing a template developed in Microsoft Excel 2007 was used, based on the methodology described by the World Health Organization. RESULTS:  In 2015, DALYs lost due to stroke, myocardial infarction, acute heart failure and chronic kidney disease were estimated at 1111, 869, 1220 and 296, respectively. The major relative weight of the lost years was given by the premature death component (96%, 85%, 82% and 93%, respectively); females contributed on average to 51.4% and 50.7% of the DALYs lost due to stroke and myocardial infarction; males contributed on average to 52.8% and 52.7% of the DALYs lost due to acute heart failure and chronic kidney disease and the most affected age was over 60 years. CONCLUSIONS: The major relative weight of the DALYs lost due to stroke, myocardial infarction, acute heart failure and chronic kidney disease of the population under program care was given by the premature death component