OBJECTIVES: The study was conducted to assess knowledge, attitude and practice (KAP) of physicians towards adverse drug reaction (ADRs) reporting and pharmacovigilance in public hospitals of Quetta city, Pakistan. Additionally, the study aimed to evaluate the correlation between knowledge, attitude and practices towards ADR reporting. METHODS: A cross-sectional study was conducted whereby physicians practicing at seven public hospitals of Quetta city, Pakistan were targeted for data collection. A self-administered questionnaire was used for data collection. Descriptive analysis was conducted through SPSS v. 20 to identify the KAP towards ADR. Spearmen rank correlation was used to identify the association among study variables and p<0.05 was taken as significant. RESULTS:  Three hundred and fourteen physicians responded to the survey. Male dominated the cohort (n= 185, 70.1%) having age ranges between 24 – 34 years (n= 175, 55.7%) and experience of between 1-10 years (n= 192, 61.1%). Majority, 230 (73.2%) of the respondents had poor knowledge about pharmacovigilance and ADR reporting system. However, 297 (94.6%) had positive attitude towards pharmacovigilance and ADR reporting system. Moreover, majority of the respondents 182 (58%) had poor practices of ADR reporting. Correlation analysis revealed significant positive association between knowledge-attitude (r=0.230, p<0.01) knowledge-practice (r=0.399, p<0.001) and attitude–practice (r=0.649, p<0.026). CONCLUSIONS: The study indicates that the respondents have an inadequate knowledge yet positive attitude toward ADR reporting and pharmacovigilance. The positive associations reveal a relationship between knowledge, attitude and practices that reports a need for educational and training programs for physicians regarding pharmacovigilance system and ADRs reporting.