OBJECTIVES: This study aimed to measure and analyze Health-Related Quality of Life (HRQOL) of general population of Sindh, Pakistan METHODS: A cross-sectional study was conducted in Karachi, Hyderabad and Sukkur. Population sample (n = 3069) was collected by using stratified sampling approach. The EQ-5D 3L tool was used to measure health-related quality of life (HRQOL) of healthy population by socio-economic demographic characteristics. The descriptive and inferential statistics have been done by using SPSS version 20. RESULTS: Result showed that mean age of respondents was 29.06 years. Maximum respondents 60.4% were female. Majority of respondents 22.8% had 10k-20k PKR income. Most of respondents 35.1% were having bachelor education. Occupation wise maximum respondents 30.9% were doing private job. Maximum 87.5% were from urban locality. 55.5% were single and most of respondents 75.5% had their own house. Total of 66 health states reported by the respondents of which most prevailing was having no problems in any domain. EQ-5D descriptive score and EQ-VAS score were 0.80 ± 0.27 and 0.80 ± 0.22 respectively. The percentage of people responding to any problems in the five EQ-5D-3L dimensions increased with age and males have better health as compared to female in all age groups. Comparison of mean score and inferential statistics shown all demographics were significantly associated (P<0.01) with mean EQ5D score and VAS. CONCLUSIONS: This study showed Sindh population HRQOL data measured by the EQ-5D tool. Current study concluded that health status of Sindh province of Pakistan people has somewhat better EQ5D index score compared to other cities of Pakistan