OBJECTIVES: This study aimed to measure and analyze Health-Related Quality of Life (HRQOL) of general population of Khyber-Pakhtunkhwa (KPK). METHODS:  A cross-sectional study was conducted in KPK. Population sample (n = 1971) was collected from Pehsawar and Sawat by using stratified sampling approach. The EQ-5D 3L tool was used to measure health-related quality of life (HRQOL) of healthy population of KPK by socio-economic demographic characteristics. The descriptive and inferential statistics have been done by using SPSS version 20 RESULTS: Result showed that mean age of respondents was 24.15 years. Maximum respondents 59.1% were female. Majority of respondents 53.3% had no any income as most of the respondents 42.8% were students. Maximum 81.4% were from urban locality. Eighty percent were single and most of respondents 85.5% had their own house. Total of 60 health states reported by the respondents of which most prevailing was having no problems in any domain. EQ-5D descriptive score and EQ-VAS score were 0.80 ± 0.24 and 0.78 ± 0.20 respectively. The percentage of people responding to any problems in the five EQ-5D-3L dimensions increased with age and females have better health as compared to male in all age groups. Comparison of mean score and inferential statistics shown all demographics were significantly associated (P<0.01) with mean EQ5D score and VAS. CONCLUSIONS: This study showed KPK population HRQOL data measured by the EQ-5D tool. Current study concluded that health status of KPK people have same EQ5D trend in which younger age have better health states which reduced as age increasing. Better female health states were observed which showed males are more prone to disease and sickness