OBJECTIVES:  : Every year in Ukraine 15-17% of the total population suffers from influenza and ARI. In Ukraine the treatment cost is 6 USD during 5 days without complications. METHODS: We used data of the MoH of Ukraine about the incidence of influenza, data of the rate of influenza vaccination, cost analysis for influenza vaccine, modeling method. RESULTS:  Number of patients with influenza and ARI in Ukraine in 2015-2016 year amounted to 5.8 mln people. The total treatment cost during 5 days without complications is 34.8 mln USD. The cost of flu vaccination is 6,87 USD (1 USD=27,5 UAH) per 1 patient in Ukraine. The rate of flu vaccination is 0.3% of the total population 2015-2016. The rate of flu vaccinations among the medical worker is 20%. Indirect costs for sick list and employee absence at work significant economic burden for the budget constitute . The minimum payment per patient for 1 day is 6 USD. It means, that the minimum payment for sick list for 5 days per patient is 30 USD and it refers to the expences of institution. In 2016 the number of economically active population was 16 million peoples. In modeling situations when 15% of people (2.4 million) is sick, the costs of sick list will be 72 mln USD, and the cost of vaccination will be 16,49 mln USD. CONCLUSIONS:  Therefore, to reduce the economic burden on the health care system and reduce indirect costs necessary to increase the rate of vaccination among the working peoples of population. Rate of benefit amount to 4,4 times higher.