OBJECTIVES:  To compare the total cost of Zika to the National Insurance System (NIS) and the Productivity Loss as a result of the absenteeism of employees in Trinidad and Tobago during the Financial Year (FY) 2016. METHODS: An average of the likely Cases of Dengue Fever reported by the Pan American Health Organization (PAHO) Epidemiological Weeks for calendar: EW 52 (2013), EW 52 (2014) and EW 53 (2015), an Expansion Factor of 15% and an estimated 20% Symptomatic cases were used to derive a comparative sample of likely Zika cases of 54555. Additionally, a ratio of the Labour Force, 645,300, and the country’s population, 1324699 (2010) was expressed as a proportion of likely cases to derive 26575. Further, the NIS Actively Insured Persons (FY2015), 519926, and the country’s Paid Employees (2015), 494828, were expressed as a proportion of the likely cases to obtain an adjusted sample of 27922. This was further adjusted to obtain a representative sample of the NIS by deriving a ratio, .007, based its claimants for Influenza (ICD-10, 168) and Flu (Unspecified) to the total Sickness Beneficiaries for the financial year July 1 to June 30 from 2013 to 2015. The result was expressed as a proportion of the likely Zika cases to obtain an adjusted sample of 188. To estimate the cost of absenteeism to the NIS, .007/188 was used to derive a Confidence Interval of ± 1 for a 4-day period using its respective rates. Productivity Loss was calculated using Daily per capita GDP PPP$ (2015) with a 3.3 conversion rate. RESULTS: The estimated Total Cost to the NIBTT was between PPP$48,589.91 and PPP$48,880.18. The estimated Productivity Loss was PPP$119,778.41. CONCLUSIONS: The estimated Cost to the economy as a result of absenteeism was greater than the cost to the National Insurance System of Trinidad and Tobago.