OBJECTIVES:  There has been increased interest in assessing patient satisfaction with consumers taking a more active role in the healthcare, its association with adherence, and its measurement is recommended by National Committee for Quality Assurance (NCQA). The aim of this study was to compare and contrast the psychometric properties of self-reported satisfaction measures designed for patients with type 2 diabetes treated with oral therapy. METHODS:  Comprehensive literature review was conducted to identify self-reported instruments in English, published in peer-reviewed journals. Psychometric properties evaluated included: conceptual model, practicality (≤15minutes to complete), breadth, depth (floor and ceiling effects ≤15%), reliability (internal consistency and test-test reliability ≤ .70), construct validity (convergent and divergent), and responsiveness. RESULTS:  Six instruments were identified for evaluation: Diabetes Medication Satisfaction Measure (Diab-MedSat), Diabetes Medication System Rating Questionnaire (DMSRQ), Diabetes Medication System Rating Questionnaire-Short Form (DMSRQ-SF), Diabetes Treatment Satisfaction Questionnaire status version (DTSQs), Diabetes Tablet Treatment Questionnaire (DTTQ), and Perceptions About Medications for Diabetes (PAM-D). The most widely used instrument is DTSQ. All instruments except for DTTQ met conceptual model criterion, and all met the practicality criterion. Diab-MedSat, DMSRQ and DMSRQ-SF encompassed the broadest aspects of satisfaction (impact on quality of life and satisfaction with efficacy, side effects, convenience, and overall). Four of six instruments met study criterion for construct validity: Diab-MedSat, DTSQs, DMSRQ and DMSRQ-SF; with three meeting reliability criterion for group level decision making, including DMSRQ, DMSRQ-SF and PAM-D. All instruments except DTTQ met the criterion of responsiveness. CONCLUSIONS:  Overall, no instruments showed ideal psychometric properties with DMSRQ and DMSRQ-SF fairing best, meeting almost all study criteria, followed by Diab-MedSat. In most cases, scales failing study criteria did so due to missing data. Instruments varied considerably in domains covered (breadth) and use in mixed diabetes populations (oral medication and insulin); therefore consideration of study objective is also critical in scale selection.