OBJECTIVES: Recently researchers at the University of Pittsburgh and University of Pittsburgh Medical Center reported the detection of KPC-positive K. pneumoniae from patients undergoing endoscopic retrograde cholangiopancreatography ((ERCP) from a single hospital. KPC-positive K. pneumoniae isolates are essentially resistant to all the commonly available antimicrobials. Therefore, it is crucial to identify them early with high accuracy to prevent it infecting other patients. With its high sensitivity and significantly lowered price, whole genome sequencing has been considered as a way to help facilitate the identification of KPC-positive K. pneumoniae