OBJECTIVES:  Antihypertensive agents, especially calcium channel blockers have been shown to inhibit oxidative stress, inflammatory response and neuroprotective. Study objective is to examine the association between antihypertensive use and risk of Parkinson’s disease (PD). METHODS: Literature search was done in PubMed, EMBASE and PsycInfo databases till Nvember 2015. Observational studies evaluating the association between antihypertensive drug use and risk of PD were included. Pooled Odds Ratio (OR) and 95% confidence intervals (CIs) were calculated using random-effects model. Subgroup and sensitivity analyses were also performed. RESULTS:  Seven relevant studies (3 case control and 4 cohort studies) were included, these consisting a of 26,63,004 subjects consisting of 12,120 PD cases. A significant association was observed between use of any antihypertensive agents especially calcium channel blockers. There was significant heterogeneity (I= 75%) and no publication bias (Beggs P= 0.2) was observed. As compared to non use of antihypertensive drugs, the pooled OR for use of angiotensin converting enzyme inhibitors is 0.99 (95% CI 0.78 - 1.20), for angiotensin II antagonists is 0.89 (95% CI 0.77 - 1.08), for beta blockers is 1.24 (95% CI 1.12 - 1.38), and for calcium channel blockers is 0.75 (95% CI 0.71 - 0.93). CONCLUSIONS: the present analysis shown that ong term use of calacium channel blockers has shown a significant reduction in risk of Parkinson's disease. However, studies with large sample size and dose relationships are required to strengthen our hypothesis.