OBJECTIVES: Little guidance is available on how to evaluate and use CER studies, creating risk for data misinterpretation and under-utilization of critical information to inform healthcare decision-makers. The aim of this study was to determine the effectiveness of a CER Certificate Program (CCP), largely derived from task-force reports and online CER Collaborative tools, on the learners’ use of evidence from CER studies. This study also assessed the CCP’s performance compared to previous data from its initial cohort. METHODS: One-hundred and seven healthcare professionals participated in a 19-hour, ACPE-approved CCP. Five self-paced, online multi-media modules utilized the CER Collaborative online tools and resources for: prospective and retrospective observational studies, indirect treatment comparisons, models, and synthesizing results from various study designs.  A live workshop engaged learners with case presentations and peer critique. Upon completion, learners assessed their ability to evaluate and use evidence from CER studies in day-to-day decision-making using a Likert scale (1= strongly disagree, 5= strongly agree). Follow-up evaluations occurred at 2 and 6 months. RESULTS: Of the 107 graduates, 103 completed post-program evaluation.  At completion, learners reported increased confidence (mean=4.3) and a 26-56% improvement in their capabilities to evaluate various CER studies. Additionally, 81% indicated an expected increase the use of evidence from CER studies in at least 1-2 problem decisions per month. Results were consistent with a previous initial cohort (N=18). At follow-up, 56% of respondents indicated they had incorporated findings from CER studies in at least two CER-related decisions at 2 months and at least six decisions at 6 months. CONCLUSIONS: As new or unfamiliar CER study designs become available, there will be an increasing need to understand how to assess the relevance and credibility of CER studies to inform decision-making. The CCP was found to consistently improve healthcare decision-makers’ self-reported abilities in assessing and applying CER in their work settings.