OBJECTIVES: Patients with Parkinson's disease (PD) experience progressive disability and reduced quality of life due to both motor and non-motor complications. The cost of illness escalates as PD progresses, placing an economic burden on the healthcare system, society and patients themselves. This research aims to estimate loss productivity, quality of life and the correlation between variables. METHODS: A cross sectional pilot survey was done   from October to December, 2015 to consecutive Parkinson diseases service patients at National Institute of Neurology and Neurosurgery (INNN) Mexico in order to analyze loss productivity and quality of life in PD, to measure the strength of the association between the two variables, we analyze the correlation coefficient in Stata. RESULTS: A total of 45 patients, 24 males, response the survey, the age mean was 61.2 years (SD± 13.23), the mean visual analogue scale (VAS) was 71.73 (SD± 18.27), the dimensions more affected in PD’s patients were mobility, pain/discomfort and anxiety/depression. There were negative correlation between the age and the VAS (-0.20). Respect to loss productivity, the percent impairment while working was 22.63% (SD± 28.84%), percent work time missed was 15.07% (SD± 6.94%), and percent overall working impairment was 77.68% (SD± 24.95%). Of all patients that had paid work the 17.65% lost their job. There was negative correlation between overall working impairment and VAS (-0.72), and there was positive correlation between overall working impairment and age (0.67). CONCLUSIONS: The chronic and progressive nature of PD results in a decrease in the health-related quality of life of patients and furthermore because of the progressive disability there was an important loss productivity in the patients with PD so this disease places a economic burden on society.