OBJECTIVES: Since health information systems (HIS) have the potential to improve the efficacy of hospitals, they are increasingly being adopted in healthcare settings. The aim of this study was to evaluate the impact of HIS on acute care hospital bed occupancy rates throughout France. METHODS: This retrospective study was based on four national databases available in 2012: oSIS (observatoire des systèmes d’information de santé), IPAQSS (indicateurs pour l’amélioration de la qualité et la sécurité des soins), Hospidiag (French hospital performance indicators), and the national accreditation database. We developed three multivariate linear regressions to estimate bed occupancy rates in medical units (model 1), surgical units (model 2), and obstetric units (model 3), which were dependent variables. The independent variables were the extent of electronic health records (EHR) use; the number of computers per capita; the number of equipment items connected to the HIS per capita; the type of hospital; the accuracy of the care; the number of beds; the number of stays with a high level of disease severity, the proportion of stays related to oncology, and the geographical region. RESULTS: In model 1 (n=434), bed occupancy rates in medical units did not appear to correlate with the development of HIS. In model 2 (n=383), increased EHRs use correlated with higher occupancy rates for surgical beds (p = 0.03). In model 3 (n=252), an increasing number of equipment items (per capita) connected to the HIS correlated with an increase in bed occupancy rates in obstetric units (p = 0.051). CONCLUSIONS: Our findings suggest that the development of HIS in acute care hospitals is associated with a higher level of bed occupancy rates for surgical and obstetric units, but not in medical units.