OBJECTIVES: Asthma is a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role: in particular, mast cells, eosinophil, T-lymphocytes, macrophages, neutrophils, and epithelial cells. In susceptible individuals, this inflammation causes recurrent episodes of wheezing, breathlessness, chest tightness, and coughing, particularly at night or in the early morning. The aim of this study was to evaluate prescribing patterns of asthma medication in a tertiary care hospital of south Punjab, Pakistan METHODS: A retrospective study design was adopted to evaluate conveniently selected 300 patient charts/prescriptions of the patients, admitted in the ward from January to April 2015. The prescriptions were evaluated using WHO prescription indicators RESULTS: Out of 300 selected cases, 247 (82.3%) patients had suffered with symptoms of asthma everyday while 25 patients had symptoms occasionally. It was found that number of drugs per prescription 5.4 (optimal ≤ 3), drugs prescribed by generic name 19.7% (optimal 100%), drugs prescribed from National Essential Drug List (NEDL) 78.4%. The prevalence of drug interactions was 50.7%. In prescribing of medicine to patients, practitioners were following standard guideline “Global Initiative for Asthma for prescribing medicines”. In most of prescriptions dose, dosage form and frequency of administration were not mentioned. CONCLUSIONS: Based on the findings of this study, it is concluded that although WHO prescribing indicators were not followed properly but practitioners were followed standard treatment guidelines of GINA