OBJECTIVES: Oral cancer accounts for 30% of all cancers in India. Oral cancer survivors have highly subjective support needs and vary in severity leading to management of changes to oral health and functioning with a significant impact on patients’ Quality of Life. To review the scientific literature for last 15 years measuring humanistic outcomes of Oral Cancer survivors in India. METHODS: A systematic review was conducted with five electronic databases (CINAHL, Pubmed, EBSCO, Medline, Google Scholar) from 2000-15. Studies assessing QoL outcomes among oral cancer patients in India published as full text journal articles in English were included and reviewed by two independent reviewers using the Delphi method. RESULTS: Out of 43 studies retrieved, only 4 met the inclusion criteria. Studies evaluating biomarkers, clinical outcomes, QoL for dental issues, jaw surgeries or other diseases and non-Indian populations were excluded. A study using EORTC QLQ-H&N-35 found main factors affecting QoL were loss of weight, use of painkillers, sticky saliva, reduced mouth opening and problems in social eating. Another study using UW-QOL found QoL in five domains was improved with significant improvement in pain scores, overall activity, recreational activities, mood and anxiety level whereas patient appearance, swallowing, chewing, speech, shoulder pain, discomfort, taste and saliva production were significantly worse. Another study reported Oral Hygiene had low impact on QoL. CONCLUSIONS: Lack of quantifiable QoL outcomes studies for Oral Cancer patients separate from Head and Neck (HNC) Cancers in India indicates a need for further research. Expanding the systematic review to HNC may yield additional results. However, oral cancers are a significant problem with different morbidity and support needs and should be addressed separately from overall HNCs. An evaluation of the QoL and concerns may help healthcare providers support and manage treatment in oral cancer survivors.