OBJECTIVES: Although pancreatic cancer is not among the most common cancers, it is predicted to be the second highest cause of cancer-related death by 2030, striking mainly people over sixty year of age and that at a rate which is not uniform across US states. To understand healthcare demand in pancreatic cancer it is therefore important to understand the age distribution and location of the population considered. The objective of this effort was to estimate the number of US patients by state and by age-group. METHODS: Publicly available information was used to obtain cancer incidence rates by state (Centers of Disease Control), national incidence rates by age group (Surveillance, Epidemiology, and End Result [SEER] database), and demographic information, population by age group, and population by state (US Census 2010). Pancreatic cancer incidence rates by state and by age group were estimated using these data. RESULTS: The estimated incidence of pancreatic cancer varied by state and by age group. Maine and Utah had the highest and lowest values, respectively, with estimated incidences of 18 and 8 per 100,000. For age groups <45 years, 45–54 years, 55–64 years, and ≥65 years the incidences per 100,000 patients ranged from 0.3, 5.8, 16.5, and 54.5, respectively to 0.5, 8.0, 23.2 and 92.5 per 100,000. CONCLUSIONS: The incidence of pancreatic cancer is approximately 14 patients per 100,000 in the US but there is considerable variation by state and age.