OBJECTIVES: Blood pressure control is poor among patients with hypertension. Low adherence to pharmacotherapy is also prevalent among hypertensive patients due in part to the nature of the disease and to the side effect of long-term pharmacotherapy. Recognizing the significant role of dietary intake in hypertension, several dietary approaches are recommended to individuals with hypertension. This review aimed to appraise published studies on the use of therapeutic water-only fasting, considered an alternative medicine technique, in the control of blood pressure among individuals with hypertension. METHODS: Included in this review were all studies published in the English language that assessed blood pressure control in a population of hypertensive patients voluntarily consuming only water for at least a period of five days. Blood pressure recorded as systolic and or diastolic pressure were the outcome measures assessed. The electronic database search included CINAHL, PubMed, Elsevier and Google Scholar. RESULTS: Two observational studies met the criteria for inclusion in this review. In the first study, 174 patients with a blood pressure of 140/90 mm Hg and higher at baseline, following an average fasting period of 10 days had an mean decline of 37/13 mm Hg in systolic and diastolic blood pressure. Similarly, the 68 patients in the second study having a blood pressure of at least 120/80 mm Hg at baseline had a mean 20/7 mm Hg decline in systolic and diastolic pressure following an average 13-day water-only fasting period. CONCLUSIONS: Therapeutic water-only fasting may be an effective therapy for reducing blood pressure among hypertensive patients. More rigorous study designs should be employed in the study of the effectiveness of this therapy in reducing blood pressure in hypertensive patients.