OBJECTIVES: Epilepsy is a common but serious brain disorder. Epilepsy can begin at any time of life, but it is most common in children under five years.The main objective of this study was to assess the pattern of antiepileptic drugs(AEDs) use in pediatric clinical practice and report the potential adverse effects of AEDs.  METHODS: This was a cross-sectional study conducted Over a six-month period, all pediatric epilepsy out- patients of age 6months to 12years from a secondary care hospital who were diagnosed with epilepsy were followed up prospectively.Data was collected and analyzed using various statistical methods.  RESULTS: Data for a total of 153 out-patients were collected, 80 were males and 73 were females with a mean age of 6.87±3.4 years. 50 patients (32.67%) had idiopathic seizure, 46 patients (30%) had focal epilepsy and 48 patients (31.37%) had generalized epilepsy while the rest 9 patients were diagnosed with febrile seizures. An average of 1.6 antiepileptic drugs per patient was prescribed.121 patients(79%) were on monotherapy , 22 patients (14.3%) were taking 2 AEDs and 10 patients(6.5%) were prescribed with three or more AEDs, Carbamazepine was the commonest monotherapy (71%) followed by Valproic acid (10.80%), and Phenytoin (9.90%).  Combination of one conventional AED with one Benzodiazepine were the most frequent 2 drug combination, while 2 conventional AEDs with one Benzodiazepine were the commonest 3 drug combination, only 3 patients (1.9%) were taking newer AEDs as add on therapy. The overall incidence of adverse drug reactions (ADRs) was 5.22% and Carbamazepine caused majority of ADRs. CONCLUSIONS: Monotherapy was the most frequently used remedy in all forms of epilepsy. Despite the availability of newer antiepileptics in secondary care settings , the domain of monotherapy was  still dominated in pharmacotherapy of epileptic seizure.