OBJECTIVES: This study aimed to understand differences in patients’ openness and preference toward biologics and biologic modes of administration (MOA), compared to physicians’ perception of the openness and preference of their patient population.  A stratified analysis was conducted to understand differences between Minority vs White responses. METHODS: Patients (N=263) and physicians (N=100) completed a self-administered web-based survey.  Patients were identified through the Sample Czar nonprofit-focused panel or All Global online consumer panel. Patients were U.S., aged ≥18, with no prior biologic experience.   Only patients that responded consistently with non-contradictory responses were included in this analysis.  170 patients responded consistently to preference questions and 169 patients responded consistently to openness questions.  In order to compare physician responses about their patient population vs. patient responses, population samples for both were derived using bootstrapping statistical techniques  (responses were randomly over sampled 10,000 times with replacement).A stratified-analysis of responses of Minority patients vs White/Undetermined patients was conducted.  Student t-tests were used to calculate p-values. Only results displaying p-values were significant. RESULTS: OPENNESS: Physicians significantly overestimated patients openness to biologics in general, (85.46% vs 74.61% respectively, p<.0001) but, underestimated patients openness to Intravenous (IV) MOA (55.97% vs. 63.96% respectively).  Minority patients (N=42) showed greater openness to biologics (92.90%), to IV MOA (83.32%), and SQ MOA (90.52%) compared to White/Undetermined patients (68.44%, 57.45%, 59.77% respectively N=127).  PREFERENCE: Overall physicians significantly underestimated patients’ preference to IV MOA (22.07% vs 24.35% respectively, p<.0001) and SQ MOA (48.84% vs 54.69 respectively p<.0001).  Minority patients (N=27) had greater preference for IV MOA (59.23%), and a lower preference to SQ MOA (40.77%) compared to White/Undetermined (39.25%, 57.24% respectively N=143).  CONCLUSIONS: The results from this study suggest differences between minority and white/undetermined patients’ openness and preferences to biologics and biologic MOA highlighting the importance of cultural factors in shared decision making.