OBJECTIVES: This study examined the impact of co-occurring chronic conditions on healthcare expenditures among community-dwelling stroke survivors. METHODS: This study adopted a retrospective, cross-sectional, propensity-score matched case-control design using Medical Expenditure Panel Survey (MEPS) data (2002-2012). The study sample consisted older adults age ≥ 50 years, alive during the calendar year, and had positive total healthcare expenditure. Stroke survivors (identified with ICD-9-CM codes of 430-438) were compared to propensity-score matched control group (non-stroke). Dependent variables consisted of total healthcare expenditures as well as inpatient, outpatient, emergency room, prescription medication, home healthcare, and other expenditures. Ordinal Least Square (OLS) regressions on log-transformed dollars were performed to compare healthcare expenditures between stroke and matched non-stroke controls. Beta coefficients estimated from OLS regression were used to estimate the percent change in expenditures between the two groups using semi-logarithmic equation (e^β – 1). All analyses accommodated for complex survey design of MEPS. RESULTS: The annual average total healthcare expenditures (expressed in 2012 United States dollars) among stroke survivors were significantly higher than matched non-stroke controls ($18,492 vs. $14,535, p<0.001). Findings from OLS regressions revealed that stroke survivors experienced 62% (β=0.483, p<0.001) higher total healthcare expenditures compared to matched non-stroke controls when only demographic characteristics were adjusted. After adding co-occurring chronic conditions to this model, it was observed that stroke survivors had 40% (β=0.338, p<0.001) higher total healthcare expenditures compared to matched non-stroke controls. In presence of co-occurring chronic conditions, stroke survivors had greater total healthcare expenditures compared to matched controls. For example stroke survivors with co-occurring hypertension had significantly higher total healthcare expenditures compared to matched controls with hypertension  ($18,294 vs. $15,476, p<0.001). Similar findings were observed with inpatient, emergency room, and prescription drug expenditures. CONCLUSIONS: Co-occurring chronic conditions partially explained the healthcare expenditure burden among a nationally representative sample of community-dwelling stroke survivors.