OBJECTIVES: Variation in health care delivery, especially in oncology treatment, is an important public health issue that requires sophisticated clinical data for comprehensive assessment. The HealthCore Integrated Research Environment (HIRE)-Oncology is a clinically-rich data source derived from Anthem’s Cancer Care Quality Program (CCQP) and integrated with administrative claims data. The study objective was to characterize chemotherapy and targeted cancer treatment patterns by cancer stage for breast, colorectal and lung cancer patients. METHODS: Breast, colorectal and lung cancer patients were identified based on CCQP requests in the HIRE-Oncology data for chemotherapy and/or targeted cancer treatments submitted between 6/1/2014 and 4/30/2015. Index date was the earliest pre-authorization date. Demographics were evaluated by cancer type. Clinical characteristics and treatment patterns were assessed by cancer type and stage. RESULTS: CONCLUSIONS: Treatment variation was present among the patients with breast, colorectal and lung cancer. This variation may have been associated with the clinical condition of the cohort, as CCQP requests were skewed toward patients with more advanced cancer stages. Integrated clinical and claims data, such as provided in the HIRE-Oncology dataset, are a key asset required to comprehensively evaluate oncology care.