OBJECTIVES: The study aimed to assess the health related quality of life (HRQoL) in hospital admitted patients of tertiary care public hospitals in Quetta, Pakistan. METHODS: A cross-sectional study was conducted to assess the HRQoL in hospital admitted patients in two major hospitals of Quetta city (Bolan Medical Complex hospital and Provincial Sandmen hospital) from April to October, 2015. European Quality of Life scale (EQ-5D 3L) was used to measure HRQoL. Inferential statistics (Mann-Whitney-U and Kruskal Wallis test, p < 0.05) were used to evaluate the significance of study. RESULTS: A total of 583 patients were included in the study, out of which  435 (74.6%) were male. One hundred twenty-two (20.9%) of respondents were from age group 21-30 years and four 460 (78.9%) were married. More than half of respondents (n=302, 51.8%) were from urban residency and 352 (60.4%) were uneducated along with 154 (26.4%) were self-employed. Majority of patients 154 (26.4%) admitted due to gastro intestinal diseases. The disease duration which dominates 145 (24.9%) from one week to one month. Three hundred and ninety-nine (68.4%) patients were satisfied with overall hospital’s facilities. The mean EQ-5D descriptive score was calculated to be 0.37± 0.32, whereas mean VAS score was calculated to be 53.39 ± 16.747. None of the demographic characteristics were significantly associated with mean EQ-5D Score except education (P < 0.01), where as Age Group, ethnicity and education. Disease type and duration of stay did not influence both EQ-5D or VAS scores of the study population (P > 0.001). CONCLUSIONS: The study conclude that the hospital admitted patients has decreased HRQoL.  It is recommended that health psychologists are to be appointed in hospitals who plan the therapeutic protocols along with the physicians for the patients to improve their coping and adjustment with their disease.