OBJECTIVES: The purpose of this study was to examine the treatment outcomes of smear positive pulmonary TB cases registered in TB patients in Quetta.  METHODS: Cross sectional retrospective cohort study was performed on TB patient in Fatima Jinnah chest hospital, Quetta. Retrospective medical records of smear-positive tuberculosis patients registered in first quarter of year 2012. Tuberculosis treatment outcomes were assessed according to WHO guidelines. The descriptive statistics was used to present the demographic and disease related information. Inferential statistics was used to  the evaluation relationship among study variables. All analyses were performed using SPSS 20.0. RESULTS: Out of the 131 TB patients (67 males and 64 females). Majority of the patients were in the age group 18-47 (73.7%). High percentage of the patients had successful treatment with treatment outcome “Completed” and  ‟cured" were 65.5% (n=74), whereas, death occurred in only 5.3% (n=7) of patients. Demographic characteristics age was the only determine factor which influence the treatment outcome in TB patients.  CONCLUSIONS: The present study concluded that majority of the TB patients had successful treatment outcome, however, efforts should be made evaluate the treatment failure particularly in elderly patients to achieve better treatment outcomes.