OBJECTIVES: To analyze the use of statins in 90 days after hemodialysis among the prior-users. METHODS: This retrospective cohort study used the 1997-2008 National Health Insurance Research Data to analyze the use of statins among prior users aged 20 years or older after they started maintenance hemodialysis. These prior users were prescribed with statins at least once in 180 days prior to hemodialysis. Discontinuation of statin prescription was defined when there was no prescription records in the following 90 days, and the date of discontinuation was coded as the last date of prescription plus medication period. We used Cox proportional hazard model to examine the potential factors attributable to the discontinuation of statin prescription. We also analyze the pattern of re-use of statins after one year. RESULTS: Among 8982 statin users, 2079 patients continued to use statins after hemodialysis. In 90 days after hemodialysis, the average medication days among the continued users was 65.8 days. Among the discontinued users, 65% stopped using statins in the 90 days before hemodialysis; 8.7% of them started using statins in the first 6 months and 19% started in the first year again. Analysis of the Cox proportional hazard model showed that being male(HR 1.10, 95% CI 1.05, 1.15) and no statin prescription in 90 days before hemodialysis(HR 1.78�, 95% CI 1.68, 1.87) were attributable to the discontinuation of statins in 90 days after hemodialysis; those with coronary heart disease(HR 0.93�, 95% CI 0.89, 0.98) and peripheral vascular disease(HR 0.87�, 95% CI 0.79, 0.96) tended to continue using statins. CONCLUSIONS: Most statin users stopped using statins after hemodialysis. In fact, most of them stopped using statins in the 90 days before hemodialysis. Subjects who were female and with medical history of cardiovascular diseases or peripheral vascular disease were more likely to continue using of statins after hemodialysis.