OBJECTIVES: Since the optimal Venous Thromboembolism (VTE) prophylaxis strategy for trauma patients is unknown, we performed this study to compare the effectiveness of the use of pharmacological thromboprophylaxis such as Low Molecular Weight Heparin (LMWH) to the non-pharmacological thromboprophylaxis such as pneumatic compression devices (PCDs) in the prevention of Deep Vein Thrombosis (DVT)  among major trauma patients. METHODS: A simplified decision-analysis model was established. The outcome measures for this model were the expected utilities resulting for each of the comparison categories. Our model compares two strategies, LMMW and PCDs. Patients who received LMWH as prophylactic approach will then have the chance to either develop DVT or not develop DVT. As some patients develop DVT the have four different chances; to die from DVT, survive DVT survive DVT but suffer from bleeding complications, or survive DVT but suffer from Heparin Induced Thrombocytopenia (HIT). The expected utility then calculated based on the terminal node utility and probability of each possible event. On the second hand, PCDs patients will either develop DVT or not based on the probabilities. If developed DVT, they might die, survive, suffer bleeding or suffer Local Tissue Injury (LTI)