OBJECTIVES: The aim of this study was to evaluate the associations between quality of life (QoL) domains and frequency of readmission to hospitals for different cancer patients. A secondary aim was to observe if the increased number of outpatient clinic admissions resulted an increased number of hospitalizations. METHODS: We evaluated QoL (EORTC QoL Questionnaire-C30) and hospital admissions in 350 patients with lung, breast, hematological, head and neck, colorectal, gastric, gynecological, and prostate cancers. The outpatient clinic admission and hospitalization data for each patient within 1-year of QoL assessment was obtained from the hospital finance database. Statistical analyses used nonparametric correlation coefficients  to flag associations (r>0.3 and p<0.05) between overall, functional or symptom scales and number of hospitalizations or outpatient clinic admissions. RESULTS: QoL domains associated with readmissions within 3 months were, emotional functioning (r=0.42, p=0.003) and global health status (r=0.51, p<0.001) for gastric cancers. For readmissions within 1 year they were nausea/vomiting symptom scales (r=0.44, p=0.002) for colorectal cancer and global health status (r=0.46, p=0.001) for gastric cancers. Constipation (r=0.32, p=0.025) and nausea/vomiting scales (r=0.32, p=0.024) for breast cancers were associated with hospitalizations within 3 months. Diarrhea symptom scale (r=0.35, p=0.013) for colorectal cancers and appetite loss scale (r=0.55, p=0.016) for prostate cancers were associated with hospitalizations within 1 year. In general, number of hospitalizations and admissions were not significantly correlated except for the head and neck cancers (r=0.32, p=0.022, within 1 year). CONCLUSIONS: Several quality of life domains might be associated with hospital admissions and hospitalizations. Although they may not always reflect causal relations, these QoL evaluations may be used to flag possible increases in contact with health care system and to timely notify the patient or their relatives of this possibility. Increased number of clinic visits does not necessarily result in increased hospitalizations for most cancer types.