OBJECTIVES: Antibiotics in clinical practice in Slovakia are often indicated unnecessarily and without proper differential diagnosis that differentiate viral form bacterial etiologic agents. Due to the frequent indications of antibiotics in praxis are consumption trends increasing, there is greater financial burden an the health care as well as we can observe unjustified consumption. In consequence the resistance of microorganisms to antibiotics is increasing. METHODS: Our work aims to give an image of the current prescribing behaviour of physicians involved in the project SKANT – The School of Antibiotic Therapy. It evaluates trends in antibiotic prescription in the treatment of respiratory diseases, the etiology of infections, antibiotic administration merits focused on Slovakia during first quarter of 2013. Implementation by validate questionnaire study of prescribing in general practitioners for adults and general practitioners for children and adolescents in Slovakia.  RESULTS: According to the evaluated data there is high consumption in the group of penicillins and macrolides. The unjustified prescription of macrolides 24.58% due to allergy of patients to penicillins 4.67%. In these respiratory diseases, antibiotics were most frequently indicated: Sinusitis acuta (79.47%), Tonsilopharyngitis acuta (69.78%), Bronchitis acuta and Tracheobronchitis acuta (68.80%) The use of microbiological and biochemical tests were observed in 26.5% of patients. In 73.5% not used any of these tests. CONCLUSIONS: Analysis of treatment with antimicrobial drugs for acute respiratory diseases confirmed the current trend of increasing prescription in Slovakia. Excessive consumption of antibiotics often leads to unwanted spread of antimicrobial resistance and the ineffectiveness of existing drugs to fight infections. The solution unfavorable situation is repeated audits of prescribing antimicrobial drugs. Based on the results of our study we suggest prepare educational training for laic and professional public.