OBJECTIVES: To investigate hospital pharmacists’ Knowledge, Attitude and Perceptions (KAP) regarding pharmacists-led interventions to reduce Adverse Drug Reactions (ADRs), Drug Interactions (DIs), and Pharmaceutical Care Issues (PCIs) towards better pharmaceutical care planning in Pakistan. METHODS: A prospective, cross-sectional and self-administered questionnaire based study was conducted in tertiary care public hospitals in Pakistan. Only registered hospital pharmacists were approached to obtain data regarding their KAP towards pharmacists-led interventions to reduce ADRs, DIs, and PCIs towards better pharmaceutical care planning. All obtained data were analyzed using descriptive and inferential statistics. RESULTS: More than two thirds of the hospital pharmacists (75%) rated physicians as the first person to contact in case of any ADRs, DIs, and PCIs. Nevertheless, very poor KAP was observed towards pharmacist’s professional role in addressing ADRs, DIs, and PCIs (79%). Unexpectedly, 42% of them were not having appropriate knowledge towards pharmacists’ role in addressing ADRs, DIs, and PCIs in PCP (79%). A total of 72.1% reported that they are familiar with the procedure of reporting ADRs. A total of 89.1% of the respondents agreed that safe, effective and patient-centered PCP plays an important role in patient safety and professional healthcare. In multivariate logistic regression, statistical correlations showed that gender and age were the persuasive predictors for the studied model. CONCLUSIONS: The findings from this study endorse that the knowledge of hospital pharmacists in Pakistan regarding their role to reduce ADRs, DIs, and PCIs towards better pharmaceutical care planning was not satisfactory. Their attitude towards learning of latest methods and procedures to address ADRs, DIs, and PCIs was satisfactory. However, pharmacists need to be more proactive and professional in playing their professional role towards better patient care.