OBJECTIVES: To assess the impact of pharmacists-led non-clinical interventions on knowledge, attitude and perception among pulmonary tuberculosis (PTB) patients in Pakistan.  METHODS: A randomized controlled non-clinical trial was piloted on PTB patients under the supervision of registered pharmacists whereby PTB patients received educational non-clinical interventions regarding knowledge, attitude and perception on PTB. Self-administered research tool was used and demographic characteristics of the patients were determined by means of descriptive statistics. Data was analyzed by using SPSS 21.0. Comparison between trial group and control group was done with the help of inferential statistics.  RESULTS: Two hundred and eighty PTB patients were randomly chosen for the study i.e. one hundred and forty in each group. No significant differences were observed in either group for mean age, gender, education level, occupation and income whereas a significant improvement (p<0.001) in the knowledge, attitude and perception was noted in the interventional group.  CONCLUSIONS: The pharmacist-led, non-clinical intervention caused a significant improvement in PTB patients’ knowledge, attitude and perception scores. This study highlights pharmacists’ need and their significantly important role towards better patient care and education. These finding are considerably useful for better disease management and control.