OBJECTIVES: This study aimed to compare and evaluate the health-related quality of life (HRQOL) in Asian end-stage renal disease (ESRD) patients treated with continuous ambulatory peritoneal dialysis (CAPD) and automated peritoneal dialysis (APD) in Singapore.  METHODS: Data used in this study were from two cross-sectional surveys conducted between 2009 and 2013. Participants were recruited from the PD centers of Singapore General Hospital and National University Hospital. The inclusion criteria were ESRD patients who have been on PD for at least 3 months and at least 21-year-old. In both surveys, participants completed the Kidney Disease Quality of Life (KDQOL) instrument and questions assessing socio-demographic characteristics. Co-morbidities, clinical, and dialysis-related variables (i.e. vintage, dialysis adequacy, dependency status [self-cared/assisted]) were retrieved from medical records. The 36-item KDQOL (KDQOL-36) was used to generate two generic summary scores (physical component summary [PCS], mental component summary [MCS]), three disease-specific scales (symptoms, effects, burden), and two health utility scores (Short Form 6-Dimension [SF-6D] and EuroQol 5-Dimension [EQ-5D]). The HRQOL of patients treated with CAPD and APD measured by the above-mentioned scales was compared using separate linear regression models with and without adjustment of variables collected.  RESULTS: Of the 382 PD patients approached, 266 were eligible and agreed to participate: 145 on CAPD (mean age: 60.8 years; female: 54.5%) and 121 on APD (mean age: 57.4 years; female: 54.5%). Without adjustment, the HRQOL of CAPD and APD patients were similar according to all measures except for KDQOL symptoms (difference: 6.2, p<0.01). With adjustments, significant differences were observed in KDQOL symptoms (7.0, p<0.01) and PCS (2.8, p<0.05) between CAPD and APD patients, suggesting that APD was associated with milder dialysis-related symptoms and better physical health. CONCLUSIONS: It appears that APD patients experience better HRQOL in some domains than CAPD patients in Singapore, although generic utility measures are not sensitive to this treatment advantage.