OBJECTIVES: MAOIs were first discovered in the 1950s and used to manage depression when few alternatives existed. MAOIs block tyramine catabolism, meaning patients consuming tyramine rich foods (e.g. cheeses, cured meats) risk increased release of noradrenaline, potentially leading to hypertensive crisis. While MAOIs still have some role in depression management, little is known about current clinical practice. This study aims to audit the usage of MAOIs from 2004-2013. METHODS: The THIN database was used to identify all patients prescribed irreversible MAOIs between 01/01/2004–31/12/2013. Dates of first MAOI prescription and first depression diagnosis were identified, along with age, social deprivation score and repeat MAOI prescriptions. RESULTS: