OBJECTIVES: This study aimed to assess the level of medication adherence among patients with different non-communicable chronic diseases in Quetta Baluchistan, Pakistan. METHODS: A cross sectional study was conducted in different non-communicable chronic diseases patient,  visiting outpatient department in public/private hospitals and clinics of Quetta, Pakistan. Morisky Medication Adherence Scale (Urdu version) was used to collect the data. The descriptive statistics was used to present the demographic and disease related information. Inferential statistics was used to  the evaluation relationship among study variables. All analyses were performed using SPSS 20.0. RESULTS: A total of 505 patients with different non- chronic diseases (Diabetes, Hypertension, Heart diseases, Asthma and others) were enrolled for the present study. The mean age of the patients was 44.9 years, majority 304 (60.2%) were females. There were 228, 134, 37, 32  and 74 patients for diabetes, hypertension, heart diseases, asthma and others respectively. There was significant statistical difference (p = 0.004) as present mean mediation adherence scores in different non-communicable chronic diseases condition (5.34, 5.05, 4.65, 4.69, 4.59 for diabetes, hypertension, heart diseases, asthma and others respectively)  CONCLUSIONS: The present study concluded that different disease conditions did affect the level of medication adherence, efforts should be made to provide specified health education to  improve medication adherence in different disease condition for better therapeutic outcome.