OBJECTIVES: The study aimed to  evaluate the level of disease state knowledge among tuberculosis patients.  METHODS: A questionnaire based cross-sectional study was carried out among patients with TB in Fatima Jinnah chest hospital Quetta.  Data was collected by a pre-tested structured questionnaire that contain twenty two (22) regarding information related to TB (including etiology, symptoms, transmission, diagnosis and treatment). The descriptive statistics was used to present the data. Inferential statistics was used to  the evaluation relationship among study variables. All analyses were performed using SPSS 20.0. RESULTS: Majority (60.0%) of the study patients were female and belong to age group of 22 to 31 years (24.28%). Majority (41.4%) of the respondents were illiterate and had received religious education(31.4%). The mean knowledge score was 11.23 ± 3.6 which is categorized as poor knowledge and posters/broachers and other printed material was reported as major source of information. No demographic characteristic was influencing the mean knowledge scores.   CONCLUSIONS: The study concluded that the TB patients had poor disease state knowledge. Efforts should be made educate the patients regardless to the demographic characteristics,  so that better disease control and further spread of infection would be prevented.