OBJECTIVES: Bleeding still a concern in surgical procedures and it is strong correlated with post-operative complications and increased hospital costs. Fibrin Sealant is wide used for this purpose, there are several commercially available fibrin sealants to reduce bleeding, but only one with the lack of bovine derivatives, which may, decreases the risk of allergic reaction. The aim of this study was to systematic review the safety and efficacy of aprotinin free hemostatic sealant for bleeding control. METHODS: The electronic databases PubMed, EMBASE, The Cochrane Central Register of Controlled Trials, Wiley and OVID, were reviewed. The date limit was set to December 31^th of 2014. Only English literature was considered. The studies included were RCTs in surgical patients, the intervention being, aprotinin free hemostatic sealant, and the comparison, conventional hemostatic techniques. The primary outcome was to evaluated blood loss and time to achieve hemostatic and the second outcome was risk of blooding transfusion.  RESULTS: