OBJECTIVES: A study was done at tertiary care hospital to find the clinical evaluations with particular identification and quality of life in schizophrenia patients. Patients visiting the psychiatry clinic were screened for psychological problems using a standard questionnaire and patients with history of psychiatry problems over a period of years.  METHODS: It was a possible observational study for 6 months in a hospital. The study enrolled 150 in-patients and out-patients with Schizophrenia. Patients were included in the study who met addition criteria after obtaining their knowledgeable permissionPatient history, principal symptoms, physical examination and computed tomography scan information were taken as the pretreatment evaluation. Antipsychotic drugs (Chlorpromazine and Haloperidol) were used in the patients to find the clinical evaluations and quality of life was analyzed.  RESULTS: A study was conducted to search the clinical profile, patient behavioural symptoms of drugs used among schizophrenia patients. A major number of patients who visited the hospital were diagnosed with different psychotic disorders. Among patients who were diagnosed with schizophrenia, 52% were males and 48% were females. Major factors were found to be family history (43%), alcohol (15%), thyroid disorders (7%), family problems (7%), and post menopausal problems (1%). Symptoms shown by the patients were abnormal behaviour (75%), smiling to self (15%), talking to self (29%), hallucinations (39%), aggressive (25%), sleeplessness (42%). Most common people affected were between 20-25 age groups (23%). CONCLUSIONS: It was concluded that patients were better recovered through treatment using Chlorpromazine and Haloperidol. Electro convulsive therapy through supportive treatment was used to improve the quality of life of the  patients.