A SYSTEMATIC REVIEW OF THE METHODOLOGICAL QUALITY OF NETWORK META-ANALYSES
Author(s)
Chambers J1, Naci H2, Wouters O2, Pyo J1, Gunjal S3, Kennedy I4, Hoey M4, Winn A5, Neumann PJ6
1Tufts Medical Center, Boston, MA, USA, 2London School of Economics, London, UK, 3Precision Health Economics, Austin, TX, USA, 4Royal Victoria Hospital, Belfast, UK, 5The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 6Center for the Evaluation of Value and Risk in Health, Institute for Clinical Research and Health Policy Studies,Tufts Medical Center, Boston, MA, USA
OBJECTIVES: To evaluate the methodological quality of published network meta-analyses (NMA). METHODS: We performed a systematic review of the NMA literature (through July 2014). For NMAs including pharmaceuticals we assessed general study characteristics, study reproducibility and transparency, methods, and reporting of findings. We compared NMAs published in higher impact factor journals with those published in lower impact factor journals, NMAs published before January 1st, 2013, with those published after that date, and studies receiving financial support from industry with those receiving financial support from non-profit institutions or that did not receive support. RESULTS: The systematic literature search identified 318 NMAs meeting our inclusion criteria. Forty-eight percent of NMAs were published after January 1st
Conference/Value in Health Info
2015-05, ISPOR 2015, Philadelphia, PA, USA
Value in Health, Vol. 18, No. 3 (May 2015)
Code
PRM121
Topic
Methodological & Statistical Research
Topic Subcategory
Confounding, Selection Bias Correction, Causal Inference
Disease
Multiple Diseases