OBJECTIVES: Patient-centered outcomes have become increasingly important and relevant in making informed healthcare decisions. However, the influence of patient’s perspective in economic evaluation studies remains unknown. This study sought to systematically review CEA studies conducted from the patient’s perspective. METHODS: PUBMED, EMBASE, and Cochrane Central database were searched through May 2014 for CEA studies that used patient’s perspective. Essential characteristics of these economic studies were extracted and compared. The reporting quality of these studies was evaluated using the ISPOR guideline, Consolidated Health Economic Evaluation Reporting Standards (CHEERS). RESULTS: A total of 21 out of 32 studies retrieved met the inclusion criteria. These studies, in average, met 17 of 24 reporting criteria specified in CHEERS, and were conducted in the US (5), Europe (6), Asia (6), and others (4). Among the 21 CEA studies, 9 evaluated pharmacotherapy and 12 non-drug intervention. Of the 8 studies that mentioned reasons for using patient’s perspective, patient’s consideration of financial burden associated with medical intervention was the most common one (7), followed by possible influence on patient adherence and utilization of resources (1). Societal (3), government (1), institutional (12), or third-party payer (2) perspectives were also used in majority of the studies. Direct medical cost generally considered in the studies were out-of-pocket costs such as copayment or co-insurance for drugs, office visits, tests, and procedures, whereas direct non-medical cost included travel and food cost. Sensitivity analyses were performed in 19 studies, and governmental agencies or university grants were the most common funding sources (14) disclosed by17 studies. CONCLUSIONS: Currently, there is a paucity of CEA studies conducted from patient’s perspective in the literature, and the reporting quality of these studies was not optimal. With the increasing focus of patient-centered outcomes in health policy research, use of patient’s perspective in economic studies should be advocated.