OBJECTIVES: Methodologies and information systems associated with health intervention costs in Canada have evolved since the Guidance Document for the Costing Process was published in 1996.  This document was produced to assist researchers undertaking economic studies of health interventions in Canada. To ensure this document is useful to researchers the Canadian Agency for Drugs and Technologies in Health (CADTH) is undertaking a major update of the document. This presentation will provide an overview of the key changes to the document, based on the availability of new information sources and methodologies. METHODS: A literature review of Canadian economic evaluations published between 2011 to 2014 was conducted by CADTH to understand how cost information is currently being used by researchers. In addition, CADTH conducted a scan of the various costing and resource use methodologies used in health care in Canada, and undertook discussions with researchers in health costing.  Based on the information obtained, required revisions and additions to the Guidance Document were identified. RESULTS: The updated Guidance Document consists of eight sections: Pharmaceuticals, Physician Services, Hospital Services, Diagnostic and Investigational Services, Non-Physician Professional Services, Community Based Services, Informal Caregiver Costs, and Other Information. These categories give way to targeted subsections, for which, detailed descriptions of cost components are provided, along with relevant data sources and guidance as to how and when researchers can apply the data. Key additions to this update include: the inclusion of newer methodologies (e.g., CMG+ costing, patient costing), more details on the various cost components and sources of data, and considerations for costing based on economic evaluation considerations (e.g. setting, perspective). CONCLUSIONS: The 2^nd edition of the Guidance Document aims to better assist Canadian researchers in appropriately identifying, measuring, and sourcing the types of costs and resources relevant for economic evaluations.